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10-CuBG had the highest open porosity before and after 180 days of immersion but without a statistically significant difference between dry-stored and 180-day water-stored samples

Human pharmacokinetics are not established

c ) PBMCs from long COVID patients in the presence of IgG, VCAM-1 or ICAM-1 blocking antibodies (n = 6 long COVID patients)

This is not a theoretical concern

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However, like other Khavinson peptides , Pinealon faces skepticism - most research conducted in Russia with limited Western replication, no FDA approval or large-scale international trials, mechanisms not fully elucidated despite decades of study, optimal dosing based on Russian protocols without rigorous dose-finding studies, and long-term safety data from clinical use rather than controlled trials